Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4025720 | 0.92 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBTSHRALDH1A1 | |
| SCHEMBL244427 | 0.88 | SCD (0.40) | PIK3CDPIK3CAPIK3CBTSHRALDH1A1 | |
| SCHEMBL241170 | 0.82 | ALDH1A1 (0.55) | TSHRALDH1A1HPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL243082 | 0.78 | SCD (0.70) | SCD | |
| SCHEMBL16432263 | 0.76 | PIK3CD (0.68) | PIK3CDPIK3CAPIK3CBTSHRALDH1A1 | |
| SCHEMBL243814 | 0.75 | ALDH1A1 (0.53) | ALDH1A1HPGDSMN1; SMN2CYP1A2HSD17B10 | |
| SCHEMBL243883 | 0.74 | SCD (0.53) | PIK3CDPIK3CAPIK3CBTSHRALDH1A1 | |
| SCHEMBL348399 | 0.74 | PIK3CD (0.48) | PIK3CDPIK3CAPIK3CBTSHRALDH1A1 | |
| SCHEMBL4025384 | 0.73 | RORC (0.35) | PIK3CDPIK3CAPIK3CBTSHRALDH1A1 | |
| SCHEMBL242203 | 0.73 | SCD (0.52) | PIK3CDPIK3CAPIK3CBSCDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054408-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | Novartis Ag (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008127349-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | NOVARTIS AG (CH) | 2008-10-23 | — | — | WO | disclosed |