Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.76 |
| ▸ | LMNA | P02545 | 3/20 | 0.76 |
| ▸ | HTT | P42858 | 2/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.76 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | GAA | P10253 | 4/20 | 0.70 |
| ▸ | POLB | P06746 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MITF | O75030 | 1/20 | 0.60 |
| ▸ | CCR6 | P51684 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4027858 | 0.90 | KDM4E (0.74) | ALDH1A1SMN1; SMN2LMNAHTTTDP1 | |
| SCHEMBL15145920 | 0.87 | GAA (0.71) | ALDH1A1SMN1; SMN2LMNAHTTTDP1 | |
| SCHEMBL4029344 | 0.87 | ALDH1A1 (0.86) | ALDH1A1SMN1; SMN2LMNAHTTTDP1 | |
| SCHEMBL4031975 | 0.87 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2LMNAHTTTDP1 | |
| SCHEMBL4031273 | 0.87 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2LMNAHTTTDP1 | |
| SCHEMBL4722661 | 0.83 | KMT2A (0.79) | ALDH1A1SMN1; SMN2LMNAHTTTDP1 | |
| SCHEMBL19299518 | 0.82 | KDM4E (0.71) | ALDH1A1SMN1; SMN2LMNAHTTTDP1 | |
| SCHEMBL4031988 | 0.81 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2LMNAHTTTDP1 | |
| SCHEMBL1569112 | 0.81 | POLB (0.62) | ALDH1A1SMN1; SMN2HTTTDP1CYP1A2 | |
| SCHEMBL11599578 | 0.81 | KMT2A (0.86) | ALDH1A1SMN1; SMN2CYP2C9GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379240-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2009-04-08 | — | — | EP | claimed |
| US-20060247280-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2006-11-02 | — | — | US | claimed |
| JP-2005506299-A | — | — | 2005-03-03 | — | — | JP | claimed |
| EP-1379240-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2004-01-14 | — | — | EP | claimed |
| WO-2002078696-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | claimed |
| US-20060247280-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2006-11-02 | — | — | US | disclosed |
| EP-1386279-A2 | METHOD FOR INHIBITING METAP2 | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002081415-A2 | METHOD FOR INHIBITING METAP2 | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060247280-A1 | Compounds and methods | METAP2, DNPEP, METAP1 | ALDH1A1 1820/4885SMN1; SMN2 4622/4885LMNA 4627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.