Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.61 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.61 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.61 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL156256 | 0.87 | NOTUM (0.82) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL23752365 | 0.86 | KDM4E (0.69) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL9392589 | 0.86 | KDM4E (0.69) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL5360223 | 0.84 | KDM4E (0.62) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL26763833 | 0.83 | KDM4E (0.66) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL13525164 | 0.83 | KDM4E (0.66) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL11710635 | 0.83 | KDM4E (0.66) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL6127792 | 0.83 | KDM4E (0.66) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL13524325 | 0.83 | KDM4E (0.66) | KDM4EALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL3656037 | 0.82 | PDK1 (0.59) | KDM4EPDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049493-A2 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | Cadila Healthcare Limited (IN) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008059513-A2 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LIMITED (IN) | 2008-05-22 | — | — | WO | disclosed |