Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 13/20 | 0.35 |
| ▸ | LIMK2 | P53671 | 13/20 | 0.35 |
| ▸ | TESK2 | Q96S53 | 6/20 | 0.35 |
| ▸ | TESK1 | Q15569 | 5/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4019011 | 0.91 | LIMK1 (0.36) | ADAMTS5LIMK1LIMK2TESK2TESK1 | |
| SCHEMBL4026653 | 0.85 | LIMK1 (0.33) | LIMK1LIMK2TESK2TESK1BMP1 | |
| SCHEMBL4017343 | 0.80 | HDAC3 (0.33) | BMP1HDAC3HDAC1HDAC2 | |
| SCHEMBL4019009 | 0.76 | LIMK1 (0.36) | LIMK1LIMK2TESK2TESK1 | |
| SCHEMBL13870039 | 0.72 | LIMK1 (0.38) | LIMK1LIMK2 | |
| SCHEMBL13901884 | 0.65 | DHODH (0.36) | LIMK1LIMK2TESK2TESK1HDAC1 | |
| SCHEMBL4017715 | 0.64 | GRM5 (0.40) | LIMK1LIMK2TESK2TESK1HDAC1 | |
| SCHEMBL28080023 | 0.60 | NPY5R (0.38) | HDAC3HDAC1HDAC2 | |
| SCHEMBL4019003 | 0.58 | LIMK1 (0.38) | LIMK1LIMK2TESK2TESK1 | |
| SCHEMBL21170664 | 0.57 | HRH3 (0.41) | LIMK1LIMK2CYP2C9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663241-B1 | 5-ARYLPYRIMIDINES AS ANTICANCER AGENTS | WYETH CORP (US) | 2009-05-27 | — | — | EP | disclosed |
| US-7524849-B2 | Antitumor agents to treat multiple drug resistant tumors; promoters of microtubule polymerization; etherification | WYETH HOLDINGS CORPORATION (US) | 2009-04-28 | — | — | US | disclosed |
| EP-1663241-A1 | 5-ARYLPYRIMIDINES AS ANTICANCER AGENTS | Wyeth Holdings Corporation (US) | 2006-06-07 | — | — | EP | disclosed |
| US-20050075357-A1 | 5-arylpyrimidines as anticancer agents | WYETH (US) | 2005-04-07 | — | — | US | disclosed |
| WO-2005030216-A1 | 5-ARYLPYRIMIDINES AS ANTICANCER AGENTS | WYETH HOLDINGS CORPORATION (US) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075357-A1 | 5-arylpyrimidines as anticancer agents | DPYD, ABCC1, ARF5 | ADAMTS5 2610/4885LIMK1 2268/4885LIMK2 1660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.