Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TRIP13 | Q15645 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13661759 | 1.00 | ESR1 (0.65) | ESR1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13663615 | 1.00 | ESR1 (0.65) | ESR1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13661744 | 1.00 | ESR1 (0.65) | ESR1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13663614 | 0.94 | ESR1 (0.57) | ESR1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13661747 | 0.94 | ESR1 (0.57) | ESR1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4201936 | 0.94 | ESR1 (0.57) | ESR1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4292917 | 0.84 | ESR1 (0.43) | ESR1CYP3A4CYP2D6CYP2C19HPGD | |
| SCHEMBL4292914 | 0.83 | ESR1 (0.47) | ESR1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13747999 | 0.81 | CYP3A4 (0.51) | ESR1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13661748 | 0.77 | MAPK9 (0.45) | ESR1CYP3A4CYP2D6CYP2C19HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150031759-A1 | Analogues of (-)Picropodophyllin, Synthesis And Uses Thereof | UNIVERSITY OF NEBRASKA - LINCOLN | 2015-01-29 | — | — | US | disclosed |
| US-8859614-B2 | Analogues of (−)-picropodophyllin, synthesis and uses thereof | University of Nebraska—Lincoln (US) | 2014-10-14 | — | — | US | disclosed |
| US-20090271879-A1 | ANALOGUES OF (-)-PICROPODOPHYLLIN, SYNTHESIS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2009-10-29 | — | — | US | disclosed |
| WO-2009100349-A1 | ANALOGUES OF (-)-PICROPODOPHYLLIN, SYNTHESIS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031759-A1 | Analogues of (-)Picropodophyllin, Synthesis And Uses Thereof | PPOX, HCCS, DHPS | ESR1 4401/4885CYP3A4 520/4885CYP2D6 326/4885 |
| US-20090271879-A1 | ANALOGUES OF (-)-PICROPODOPHYLLIN, SYNTHESIS AND USES THEREOF | PPOX, HCCS, DHPS | ESR1 4320/4885CYP3A4 566/4885CYP2D6 302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.