Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 10/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4026878 | 0.81 | NOTUM (0.42) | NOTUMPDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL4026817 | 0.79 | HTT (0.37) | NOTUMPDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL4026822 | 0.79 | HTT (0.37) | NOTUMPDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL6598308 | 0.72 | ALOX15 (0.55) | ALDH1A1LMNAALOX15NPSR1 | |
| SCHEMBL1447738 | 0.69 | PDE1C (0.39) | PDE1APDE1BPDE1CALDH1A1NPSR1 | |
| SCHEMBL3551145 | 0.68 | ALOX15 (0.43) | ALDH1A1LMNAALOX15NPSR1 | |
| SCHEMBL3625293 | 0.68 | ALOX15 (0.38) | ALDH1A1LMNAALOX15NPSR1 | |
| SCHEMBL6106298 | 0.65 | MAPK1 (0.40) | ALDH1A1LMNA | |
| SCHEMBL2281613 | 0.64 | MAPK1 (0.33) | ALDH1A1LMNAALOX15NPSR1 | |
| SCHEMBL4021051 | 0.64 | ALOX15 (0.44) | ALDH1A1LMNAALOX15NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485375-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2009-06-17 | — | — | EP | disclosed |