Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.57 |
| ▸ | KDR | P35968 | 11/20 | 0.57 |
| ▸ | INSR | P06213 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4026982 | 0.90 | IGF1R (0.55) | IGF1RFGFR1KDRINSR | |
| SCHEMBL3950749 | 0.88 | IGF1R (0.67) | IGF1RFGFR1KDRINSRLMNA | |
| SCHEMBL4032312 | 0.86 | IGF1R (0.52) | IGF1RFGFR1KDRINSRPLK4 | |
| SCHEMBL4031157 | 0.83 | IGF1R (0.78) | IGF1RFGFR1KDRINSR | |
| SCHEMBL4032661 | 0.82 | IGF1R (0.59) | IGF1RFGFR1KDRINSRPLK4 | |
| SCHEMBL5096885 | 0.77 | IGF1R (0.62) | IGF1RFGFR1KDRINSR | |
| SCHEMBL5096988 | 0.76 | IGF1R (0.59) | IGF1RFGFR1KDRINSR | |
| SCHEMBL3940507 | 0.76 | IGF1R (0.66) | IGF1RFGFR1KDRINSR | |
| SCHEMBL4010199 | 0.75 | IGF1R (0.49) | IGF1RFGFR1KDRINSR | |
| SCHEMBL4032918 | 0.75 | IGF1R (0.54) | IGF1RFGFR1KDRINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009019518-A1 | PYRIMIDINE COMPOUNDS HAVING A FGFR INHIBITORY EFFECT | ASTRAZENECA AB (SE) | 2009-02-12 | — | — | WO | disclosed |