Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIMP3 | P35625 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | RECQL | P46063 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | PKM | P14618 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | BRCA1 | P38398 | 3/20 | 0.50 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | APEX1 | P27695 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | STAT1 | P42224 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21033369 | 0.79 | TIMP3 (0.68) | TIMP3MEN1KMT2ARECQLHSD17B10 | |
| SCHEMBL1902159 | 0.75 | TIMP3 (1.00) | TIMP3MEN1KMT2ARECQLHSD17B10 | |
| SCHEMBL31722454 | 0.74 | KMT2A (0.54) | TIMP3MEN1KMT2ARECQLHSD17B10 | |
| SCHEMBL11342918 | 0.74 | KMT2A (0.54) | TIMP3MEN1KMT2ARECQLHSD17B10 | |
| SCHEMBL11337777 | 0.74 | TIMP3 (0.54) | TIMP3MEN1KMT2ARECQLHSD17B10 | |
| SCHEMBL11496644 | 0.74 | TRPV1 (0.55) | TIMP3MEN1KMT2ARECQLHSD17B10 | |
| SCHEMBL11348122 | 0.73 | KMT2A (0.51) | TIMP3MEN1KMT2ARECQLHSD17B10 | |
| SCHEMBL11766235 | 0.73 | KMT2A (0.54) | TIMP3MEN1KMT2ARECQLHSD17B10 | |
| SCHEMBL11766279 | 0.73 | KMT2A (0.56) | TIMP3MEN1KMT2ARECQLHSD17B10 | |
| SCHEMBL11339069 | 0.72 | KMT2A (0.53) | TIMP3MEN1KMT2ARECQLHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049127-A2 | N-METHANOCARBA DERIVATIVES TO TREAT CARDIAC DISEASES | University of Connecticut (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2007139775-A2 | N-METHANOCARBA DERIVATIVES TO TREAT CARDIAC DISEASES | UNIVERSITY OF CONNECTICUT (US) | 2007-12-06 | — | — | WO | disclosed |