Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIMP3 | P35625 | 6/20 | 0.68 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | RECQL | P46063 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | PKM | P14618 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | BRCA1 | P38398 | 3/20 | 0.50 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | APEX1 | P27695 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | STAT1 | P42224 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11598268 | 0.83 | TIMP3 (0.65) | TIMP3MEN1KMT2ARECQLHSD17B10 | |
| SCHEMBL4027006 | 0.79 | TIMP3 (0.60) | TIMP3MEN1KMT2ARECQLHSD17B10 | |
| SCHEMBL16705175 | 0.78 | ENPP2 (0.54) | KMT2ARECQLMAPTKDM4EPOLB | |
| SCHEMBL11348333 | 0.76 | TIMP3 (0.59) | TIMP3MEN1KMT2ARECQLHSD17B10 | |
| SCHEMBL11342482 | 0.76 | TIMP3 (0.59) | TIMP3MEN1KMT2ARECQLHSD17B10 | |
| SCHEMBL1902159 | 0.75 | TIMP3 (1.00) | TIMP3MEN1KMT2ARECQLHSD17B10 | |
| SCHEMBL11350653 | 0.75 | TIMP3 (0.55) | TIMP3ENPP2HPSEPRMT1SIRT1 | |
| SCHEMBL11340825 | 0.75 | TIMP3 (0.55) | TIMP3MEN1KMT2ARECQLHSD17B10 | |
| SCHEMBL20687395 | 0.75 | TIMP3 (0.67) | TIMP3MEN1KMT2ARECQLHSD17B10 | |
| SCHEMBL15887035 | 0.75 | TIMP3 (0.48) | TIMP3MEN1KMT2APKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190160029-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190160029-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION | VASP, MYLK, EDNRB | TIMP3 506/4885MEN1 4338/4885KMT2A 3904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.