Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4022010 | 0.89 | KMT2A (0.60) | MEN1KMT2ATRPV1ALDH1A1KDM4E | |
| SCHEMBL2359677 | 0.87 | KDM4E (0.56) | MEN1KMT2ATRPV1ALDH1A1KDM4E | |
| SCHEMBL3201877 | 0.83 | TRPV1 (0.51) | MEN1KMT2ATRPV1ALDH1A1KDM4E | |
| SCHEMBL4022354 | 0.83 | MEN1 (0.43) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL4435631 | 0.82 | NPC1 (0.55) | MEN1KMT2AHPGDPOLBLMNA | |
| SCHEMBL14549202 | 0.82 | KDM4E (0.52) | MEN1KMT2ATRPV1ALDH1A1KDM4E | |
| SCHEMBL29773631 | 0.81 | METAP1 (0.46) | MEN1KMT2ATRPV1ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL11403968 | 0.80 | KDM4E (0.50) | MEN1KMT2ATRPV1ALDH1A1KDM4E | |
| SCHEMBL28304457 | 0.80 | NTRK1 (0.49) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL28565556 | 0.78 | MEN1 (0.40) | MEN1KMT2ATRPV1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478363-B1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LAB (US) | 2009-01-14 | — | — | EP | claimed |
| EP-1478363-B1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LAB (US) | 2009-01-14 | — | — | EP | disclosed |