Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | EDNRA | P25101 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.47 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4028215 | 0.89 | MEN1 (0.46) | KMT2AMEN1EDNRAALDH1A1HPGD | |
| SCHEMBL2359677 | 0.86 | KDM4E (0.56) | KMT2AMEN1EDNRAALDH1A1HPGD | |
| SCHEMBL1900214 | 0.82 | RXFP1 (0.66) | KMT2AMEN1RXFP1ALDH1A1HPGD | |
| SCHEMBL29773631 | 0.80 | METAP1 (0.46) | KMT2AMEN1EDNRARXFP1ALDH1A1 | |
| SCHEMBL28175303 | 0.79 | MEN1 (0.55) | KMT2AMEN1RXFP1ALDH1A1HPGD | |
| SCHEMBL3201877 | 0.79 | TRPV1 (0.51) | KMT2AMEN1ALDH1A1HPGDKDM4E | |
| SCHEMBL4435631 | 0.78 | NPC1 (0.55) | KMT2AMEN1RXFP1HPGDMAPT | |
| SCHEMBL8923243 | 0.78 | ALDH1A1 (0.66) | KMT2AMEN1EDNRARXFP1ALDH1A1 | |
| SCHEMBL269101 | 0.78 | MEN1 (0.60) | KMT2AMEN1EDNRAALDH1A1HPGD | |
| SCHEMBL3962470 | 0.76 | TRPV1 (0.48) | KMT2AMEN1ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478363-B1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LAB (US) | 2009-01-14 | — | — | EP | claimed |
| EP-1478363-B1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LAB (US) | 2009-01-14 | — | — | EP | disclosed |