SCHEMBL28304457

SCHEMBL28304457

O=C(O)Nc1cccc2c(-c3ccccc3)nccc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 6/20 0.49
NTRK3 Q16288 1/20 0.49
HTR2B P41595 1/20 0.41
HTR5A P47898 1/20 0.41
TDO2 P48775 1/20 0.41
KDM4E B2RXH2 4/20 0.41
ALDH1A1 P00352 2/20 0.41
CHRNB2 P17787 1/20 0.40
CHRNB4 P30926 1/20 0.40
CHRNA3 P32297 1/20 0.40
CHRNA4 P43681 1/20 0.40
HPGD P15428 2/20 0.40
NQO2 P16083 1/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
PDE3B Q13370 1/20 0.40
PDE3A Q14432 1/20 0.40
LMNA P02545 2/20 0.40
PARP14 Q460N5 1/20 0.40
NPC1 O15118 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4028215 0.80 MEN1 (0.46) NTRK1NTRK3KDM4EALDH1A1HPGD
SCHEMBL2195163 0.79 NTRK1 (0.60) NTRK1NTRK3KDM4EMEN1KMT2A
SCHEMBL14549202 0.78 KDM4E (0.52) KDM4EALDH1A1CHRNB2CHRNB4CHRNA3
Hydrochloric Acid SCHEMBL11403968 0.76 KDM4E (0.50) KDM4EALDH1A1CHRNB2CHRNB4CHRNA3
SCHEMBL4022354 0.76 MEN1 (0.43) KDM4EALDH1A1HPGDMEN1KMT2A
SCHEMBL28565556 0.75 MEN1 (0.40) KDM4EALDH1A1MEN1KMT2A
SCHEMBL11976465 0.74 NQO2 (0.49) HTR2BHTR5ATDO2KDM4EALDH1A1
SCHEMBL11260165 0.74 PSMD14 (0.50) KDM4EALDH1A1HPGDMEN1KMT2A
SCHEMBL11445824 0.74 KDM4E (0.40) HTR2BHTR5ATDO2KDM4ENQO2
SCHEMBL30631719 0.73 PLG (0.54) NTRK3HTR2BHTR5ATDO2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109956900-B Compounds and pharmaceutical compositions comprising the same 财团法人工业技术研究院 2023-02-03 CN disclosed
CN-109956900-A Compound and pharmaceutical composition comprising it 财团法人工业技术研究院 2019-07-02 CN disclosed