Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL279078 | 0.80 | KCNH2 (0.35) | CDK2KCNH2CCNT1CDK9POLB | |
| SCHEMBL4022591 | 0.77 | CDK2 (0.36) | CDK2KCNH2TGFBR1TGFBR2ATM | |
| SCHEMBL1713226 | 0.71 | ALDH1A1 (0.46) | MAPK1 | |
| SCHEMBL1713315 | 0.70 | NOTUM (0.38) | CDK2MAPK1 | |
| SCHEMBL1447556 | 0.70 | CDK2 (0.40) | CDK2 | |
| SCHEMBL1447759 | 0.68 | CDK2 (0.40) | CDK2CCNT1CDK9SMN1; SMN2CDK1 | |
| SCHEMBL4031026 | 0.68 | CDK2 (0.37) | CDK2CCNT1CDK9CDK1PIK3CA | |
| SCHEMBL4243666 | 0.67 | GAA (0.41) | CDK2SMN1; SMN2MAPK1PIK3CA | |
| SCHEMBL4026878 | 0.67 | NOTUM (0.42) | CDK2MAPK1ATM | |
| SCHEMBL1204351 | 0.66 | ALDH1A1 (0.36) | POLBSMN1; SMN2MAPK1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485375-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2009-06-17 | — | — | EP | disclosed |