Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 3/20 | 0.42 |
| ▸ | BACE1 | P56817 | 3/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.34 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | FASN | P49327 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4020718 | 0.85 | CTSD (0.39) | BTKCTSDBACE1BACE2SSTR4 | |
| SCHEMBL4020947 | 0.84 | BTK (0.45) | BTKCTSDBACE1BACE2LMNA | |
| SCHEMBL3942662 | 0.80 | BTK (0.42) | BTKCTSDBACE1BACE2LMNA | |
| SCHEMBL23343850 | 0.80 | SSTR4 (0.50) | SSTR4SMN1; SMN2HSD17B10EPHX2 | |
| SCHEMBL17147985 | 0.77 | SSTR4 (0.39) | CTSDBACE1BACE2LMNASSTR4 | |
| SCHEMBL20047617 | 0.76 | BTK (0.49) | BTKLMNAANPEPSMN1; SMN2TSHR | |
| SCHEMBL863425 | 0.76 | BTK (0.49) | BTKLMNAANPEPSMN1; SMN2TSHR | |
| SCHEMBL14436576 | 0.76 | BTK (0.49) | BTKLMNAANPEPSMN1; SMN2TSHR | |
| SCHEMBL18628568 | 0.74 | BTK (0.47) | BTKLMNAANPEPSMN1; SMN2TSHR | |
| SCHEMBL3936142 | 0.73 | CTSD (0.43) | BTKCTSDBACE1BACE2ANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009013293-A1 | SUBSTITUTED CYCLOHEXANECARBOXAMIDES USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2009-01-29 | — | — | WO | disclosed |