SCHEMBL4020718

SCHEMBL4020718

CCC(=O)NC(C)(C)[C@H]1CCC[C@@H](C(=O)OC)C1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSD P07339 2/20 0.39
BACE1 P56817 2/20 0.39
BACE2 Q9Y5Z0 2/20 0.39
SMN1; SMN2 Q16637 3/20 0.37
FKBP1A P62942 1/20 0.35
ALDH1A1 P00352 2/20 0.33
SSTR4 P31391 1/20 0.33
BTK Q06187 1/20 0.33
GAA P10253 1/20 0.33
CHRNB2 P17787 2/20 0.33
CHRNA4 P43681 2/20 0.33
CHRNB4 P30926 1/20 0.33
CHRNA3 P32297 1/20 0.33
CHRNA7 P36544 1/20 0.33
CHRM2 P08172 1/20 0.32
CHRM4 P08173 1/20 0.32
CHRM3 P20309 1/20 0.32
HSD17B10 Q99714 1/20 0.32
ADRB2 P07550 1/20 0.31
ADRB1 P08588 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4028317 0.85 BTK (0.43) CTSDBACE1BACE2SMN1; SMN2SSTR4
SCHEMBL3942643 0.85 SMN1; SMN2 (0.39) CTSDBACE1BACE2SMN1; SMN2FKBP1A
SCHEMBL4030544 0.85 SMN1; SMN2 (0.39) CTSDBACE1BACE2SMN1; SMN2FKBP1A
SCHEMBL20047572 0.80 ALDH1A1 (0.38) SMN1; SMN2FKBP1AALDH1A1BTKGAA
SCHEMBL20043197 0.79 CHRNB2 (0.43) SMN1; SMN2ALDH1A1BTKCHRNB2CHRNA4
SCHEMBL20047644 0.79 CHRNB2 (0.43) SMN1; SMN2ALDH1A1BTKCHRNB2CHRNA4
SCHEMBL20351887 0.79 CHRNB2 (0.43) SMN1; SMN2ALDH1A1BTKCHRNB2CHRNA4
SCHEMBL23343850 0.77 SSTR4 (0.50) SMN1; SMN2ALDH1A1SSTR4HSD17B10
SCHEMBL3945053 0.76 KMT2A (0.37) SMN1; SMN2ALDH1A1BTKCHRNB2CHRNA4
SCHEMBL17147985 0.75 SSTR4 (0.39) CTSDBACE1BACE2SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009013293-A1 SUBSTITUTED CYCLOHEXANECARBOXAMIDES USEFUL AS BACE INHIBITORS NOVARTIS AG (CH) 2009-01-29 WO disclosed