Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | TLR2 | O60603 | 2/20 | 0.48 |
| ▸ | TLR1 | Q15399 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2473653 | 0.89 | KMT2A (0.47) | KMT2AALDH1A1NPC1TLR2TLR1 | |
| SCHEMBL2493317 | 0.84 | RORC (0.46) | KMT2ARAB9AALDH1A1MEN1CACNA1G | |
| SCHEMBL2496581 | 0.79 | MEN1 (0.47) | KMT2ARAB9ANPC1MEN1CYP3A4 | |
| SCHEMBL2469517 | 0.79 | TAAR1 (0.47) | KMT2AALDH1A1MEN1TAAR1SMN1; SMN2 | |
| SCHEMBL2473161 | 0.78 | NPC1 (0.49) | RAB9AALDH1A1NPC1CYP3A4CYP2C19 | |
| SCHEMBL2467016 | 0.77 | LTA4H (0.43) | KMT2AALDH1A1MEN1CACNA1GTAAR1 | |
| SCHEMBL2472974 | 0.77 | KMT2A (0.57) | KMT2ARAB9AALDH1A1NPC1TLR2 | |
| SCHEMBL2472016 | 0.77 | KMT2A (0.47) | KMT2AALDH1A1NPC1MEN1CYP3A4 | |
| SCHEMBL2473558 | 0.77 | MCHR1 (0.46) | KMT2AALDH1A1MEN1TAAR1 | |
| SCHEMBL4038012 | 0.77 | HTR2A (0.45) | RAB9AALDH1A1NPC1PKMTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501467-A4 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2009-08-19 | — | — | EP | disclosed |
| EP-1501467-A2 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | Bristol-Myers Squibb Company (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003088908-A2 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-10-30 | — | — | WO | disclosed |