SCHEMBL4029283

SCHEMBL4029283

[CH2]C#CCc1cccnc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 3/20 0.48
CYP1A2 P05177 2/20 0.48
CHRNA7 P36544 2/20 0.47
CHRNB2 P17787 4/20 0.46
CHRNA4 P43681 4/20 0.46
CYP2A6 P11509 3/20 0.44
NAPRT Q6XQN6 1/20 0.44
CYP2E1 P05181 2/20 0.43
CYP3A4 P08684 2/20 0.43
CYP2C9 P11712 2/20 0.43
CYP2B6 P20813 2/20 0.43
CYP2C19 P33261 2/20 0.43
TDP1 Q9NUW8 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
ESR1 P03372 1/20 0.42
CYP19A1 P11511 1/20 0.42
HRH1 P35367 2/20 0.42
CYP2C8 P10632 1/20 0.42
ALDH1A1 P00352 1/20 0.42
LTA4H P09960 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17039185 0.80 CHRNB2 (0.50) CYP2D6CYP1A2CHRNA7CHRNB2CHRNA4
SCHEMBL4575811 0.79
SCHEMBL17039122 0.78 CHRNB2 (0.50) CYP2D6CYP1A2CHRNA7CHRNB2CHRNA4
SCHEMBL6132817 0.77 CYP1A2 (0.65) CYP2D6CYP1A2TDP1ALDH1A1LTA4H
SCHEMBL17036495 0.76 CHRNB2 (0.46) CYP2D6CYP1A2CHRNA7CHRNB2CHRNA4
SCHEMBL272334 0.75
SCHEMBL4358547 0.75
SCHEMBL2560125 0.75
SCHEMBL3207879 0.75
SCHEMBL5368313 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7034150-B2 Processes for the preparation of carbapenem-type antibacterial agents SANKYO COMPANY, LIMITED (JP) 2006-04-25 US claimed
EP-2978317-A1 METHODS OF CONTROLLING NEONICOTINOID RESISTANT PESTS Syngenta Participations AG (CH) 2016-02-03 EP disclosed
WO-2014154486-A1 METHODS OF CONTROLLING NEONICOTINOID RESISTANT PESTS SYNGENTA PARTICIPATIONS AG (CH) 2014-10-02 WO disclosed
EP-1296972-B1 ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS AVENTIS PHARMA INC (US) 2009-12-23 EP disclosed
EP-1177181-B1 SUBSTITUTED BICYCLIC COMPOUNDS AVENTIS PHARMA LTD (GB) 2009-01-28 EP disclosed
US-7473669-B2 Substituted 4,5-dihydro-1,2,4-triazin-6-ones, 1,2,4-triazin-6-ones, and their use as fungicides DOW AGROSCIENCES LLC (US) 2009-01-06 US disclosed
EP-1051397-B1 METHOD FOR PREPARING AN N- (ALIPHATIC OR AROMATIC)CARBONYL -2-AMINOACETAMIDE COMPOUND AND A CYCLYZED COMPOUND AVENTIS PHARMA INC (US) 2008-12-31 EP disclosed
US-7361663-B2 N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa AVENTIS PHARMACEUTICALS INC. (US) 2008-04-22 US disclosed
EP-1881966-A2 SUBSTITUTED 4,5-DIHYDRO-1,2,4-TRIAZIN-6-ONES, 1,2,4-TRIANZIN-6-ONES, AND THEIR USE AS FUNGICIDES Dow AgroSciences LLC (US) 2008-01-30 EP disclosed
EP-1392306-B1 SUBSTITUTED TETRAHYDROISOQUINOLINES FOR USE IN THE TREATMENT OF INFLAMMATORY DISEASES AVENTIS PHARMA LTD (GB) 2008-01-16 EP disclosed
WO-2000049005-A1 BICYCLIC COMPOUNDS AND THEIR USE AS INTEGRIN RECEPTOR LIGANDS AVENTIS PHARMA LIMITED (GB) 2000-08-24 WO disclosed
EP-1027328-A1 SUBSTITUTED ANILIDES Aventis Pharma Limited (GB) 2000-08-16 EP disclosed
WO-2000039103-A1 DIHYDRO-BENZO(1,4)OXAZINES AND TETRAHYDROQUINOXALINES AVENTIS PHARMA LIMITED (GB) 2000-07-06 WO disclosed
WO-2000015612-A1 AZA-BICYCLES WHICH MODULATE THE INHIBITION OF CELL ADHESION AVENTIS PHARMA LIMITED (GB) 2000-03-23 WO disclosed
WO-1999048870-A1 PIPERIDIDINYL AND N-AMIDINOPIPERIDINYL DERIVATIVES AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) 1999-09-30 WO disclosed
WO-1999038844-A1 METHOD FOR PREPARING AN N-[(ALIPHATIC OR AROMATIC)CARBONYL]-2-AMINOACETAMIDE COMPOUND AND A CYCLYZED COMPOUND AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) 1999-08-05 WO disclosed
WO-1999023063-A1 SUBSTITUTED ANILIDES AVENTIS PHARMA LIMITED (GB) 1999-05-14 WO disclosed
EP-0551993-B1 Pyrrolidine derivatives and process for preparing the same SUMITOMO PHARMA (JP) 1996-07-10 EP disclosed
US-5322952-A Pyrrolidine derivatives and process for preparing the same SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1994-06-21 US disclosed
EP-0551993-A1 Pyrrolidine derivatives and process for preparing the same SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1993-07-21 EP disclosed