SCHEMBL4029285

SCHEMBL4029285

CC1(C)NC(=S)N(c2ccc(C#N)c(C(F)(F)F)c2)C1=N

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 12/20 0.62
ABCG2 Q9UNQ0 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2221478 0.87 AR (0.78) AR
SCHEMBL4032142 0.86 AR (0.80) AR
SCHEMBL1715663 0.83 AR (0.53) AR
SCHEMBL8478751 0.82 AR (0.51) AR
SCHEMBL8004308 0.81 AR (0.60) AR
SCHEMBL4023040 0.81 AR (0.75) AR
SCHEMBL4025432 0.79 AR (0.59) ARABCG2
SCHEMBL4025731 0.78 AR (0.58) AR
SCHEMBL1715935 0.77 AR (0.64) ARABCG2
SCHEMBL4031610 0.77 AR (0.80) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009097996-A1 USE OF SUBSTITUTED PHENYLIMIDAZOLIDINES FOR PRODUCING MEDICAMENTS FOR TREATING METABOLIC SYNDROME SANOFI-AVENTIS (FR) 2009-08-13 WO disclosed
EP-0671156-B1 Process to prepare cosmetic or pharmaceutical compositions containing liposomes AVENTIS PHARMA SA (FR) 2001-10-24 EP disclosed
US-6162444-A Cosmetic or pharmaceutical compositions HOECHST MARION ROUSSEL (FR) 2000-12-19 US disclosed
US-RE35956-E Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1998-11-10 US disclosed
US-5627201-A Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1997-05-06 US disclosed
EP-0494819-B1 Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 1996-07-10 EP disclosed
EP-0671156-A1 Cosmetic or pharmaceutical compositions containing liposomes ROUSSEL UCLAF (FR) 1995-09-13 EP disclosed
US-5411981-A Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1995-05-02 US disclosed
EP-0494819-A1 Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 1992-07-15 EP disclosed