SCHEMBL4032142

SCHEMBL4032142

CC1(C)NC(=S)N(c2ccc(C#N)c(C(F)(F)F)c2)C1=O

nearest known ligand 0.80

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 12/20 0.80
PGR P06401 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL629858 0.89 AR (1.00) ARPGR
SCHEMBL4029285 0.86 AR (0.62) AR
Acetic Acid SCHEMBL7784177 0.84 AR (0.89) ARPGR
SCHEMBL14620477 0.83 AR (0.61) AR
SCHEMBL1716347 0.83 AR (0.61) AR
SCHEMBL1716338 0.82 AR (0.63) ARPGR
SCHEMBL4031754 0.81 AR (0.79) ARPGR
SCHEMBL12812542 0.81 AR (0.53) AR
SCHEMBL4023707 0.81 AR (0.73) ARPGR
SCHEMBL14218626 0.81 AR (0.60) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE35956-E Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1998-11-10 US claimed
US-5627201-A Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1997-05-06 US claimed
EP-0494819-B1 Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 1996-07-10 EP claimed
US-5411981-A Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1995-05-02 US claimed
EP-0494819-A1 Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 1992-07-15 EP claimed
US-11739075-B2 Cereblon binding compounds, compositions thereof, and methods of treatment therewith CELGENE CORPORATION (US) 2023-08-29 US disclosed
US-20230158152-A1 PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME MEDSHINE DISCOVERY INC. (CN) 2023-05-25 US disclosed
EP-4122925-A1 PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME Medshine Discovery Inc. (CN) 2023-01-25 EP disclosed
US-11560371-B2 Cereblon binding compounds, compositions thereof, and methods of treatment therewith CELGENE CORPORATION (US) 2023-01-24 US disclosed
US-11427548-B2 Compounds and methods for the targeted degradation of androgen receptor ARVINAS OPERATIONS, INC. (US) 2022-08-30 US disclosed
US-20170313662-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF ENZALUTAMIDE LAURUS LABS LIMITED (IN) 2017-11-02 US disclosed
WO-2016051423-A2 AN IMPROVED PROCESS FOR THE PREPARATION OF ENZALUTAMIDE LAURUS LABS PRIVATE LIMITED (IN) 2016-04-07 WO disclosed
EP-0671156-B1 Process to prepare cosmetic or pharmaceutical compositions containing liposomes AVENTIS PHARMA SA (FR) 2001-10-24 EP disclosed
US-6162444-A Cosmetic or pharmaceutical compositions HOECHST MARION ROUSSEL (FR) 2000-12-19 US disclosed
US-RE35956-E Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1998-11-10 US disclosed
US-5627201-A Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1997-05-06 US disclosed
EP-0494819-B1 Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 1996-07-10 EP disclosed
EP-0671156-A1 Cosmetic or pharmaceutical compositions containing liposomes ROUSSEL UCLAF (FR) 1995-09-13 EP disclosed
US-5411981-A Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1995-05-02 US disclosed
EP-0494819-A1 Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 1992-07-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170313662-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF ENZALUTAMIDE KLK4, KLK5, KLK1 AR 8/4885PGR 2547/4885
US-20230158152-A1 PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME PSMA6, PSMC1, PSMA1 AR 1545/4885PGR 3724/4885
US-11739075-B2 Cereblon binding compounds, compositions thereof, and methods of treatment therewith CRBN, AR, ESRRA AR 2/4885PGR 42/4885
US-11560371-B2 Cereblon binding compounds, compositions thereof, and methods of treatment therewith CRBN, AR, SHBG AR 2/4885PGR 70/4885
US-11427548-B2 Compounds and methods for the targeted degradation of androgen receptor AR, MDM2, ESRRA AR 1/4885PGR 501/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.