Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 5/20 | 0.43 |
| ▸ | CA1 | P00915 | 5/20 | 0.43 |
| ▸ | CA2 | P00918 | 5/20 | 0.43 |
| ▸ | CA9 | Q16790 | 5/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032932 | 0.70 | MAPT (0.51) | TP53LMNAMAPTKDM4EMEN1 | |
| SCHEMBL4446760 | 0.70 | MEN1 (0.55) | MAPTMEN1KMT2ACA12CA1 | |
| SCHEMBL5101123 | 0.70 | MAPT (0.53) | TP53LMNAMAPTALDH1A1POLB | |
| SCHEMBL23291147 | 0.69 | LTA4H (0.53) | KDM4ECA12CA1CA2CA9 | |
| SCHEMBL4656567 | 0.69 | S1PR1 (0.60) | CA12CA1CA2CA9SIGMAR1 | |
| SCHEMBL24920672 | 0.69 | CA12 (0.67) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL5100503 | 0.69 | LMNA (0.54) | TP53LMNAMAPTPOLB | |
| SCHEMBL13886735 | 0.69 | NPC1 (0.57) | MAPTMEN1KMT2ACA12CA1 | |
| SCHEMBL23291302 | 0.69 | HRH3 (0.61) | MAPTSIGMAR1POLB | |
| SCHEMBL23291176 | 0.69 | HRH3 (0.55) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569916-B1 | SUBSTITUTED ARALKYL DERIVATIVES | CADILA HEALTHCARE LTD (IN) | 2009-01-07 | — | — | EP | claimed |