Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 11/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.41 |
| ▸ | RELA | Q04206 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032717 | 1.00 | GAA (0.48) | GAAMAPTRAB9AALDH1A1NPC1 | |
| SCHEMBL372771 | 0.78 | CHRNA7 (0.43) | MAPTRAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL4030335 | 0.76 | GPR52 (0.39) | ALDH1A1KMT2AMEN1HPGDGPR52 | |
| SCHEMBL4027794 | 0.74 | CHRNA7 (0.58) | MAPTRAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL4029015 | 0.74 | CHRNA7 (0.41) | MAPTALDH1A1KMT2AALOX15GPR52 | |
| SCHEMBL4033241 | 0.74 | CHRNA7 (0.58) | MAPTRAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL5218110 | 0.72 | MEN1 (0.45) | GAAMAPTALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4031687 | 0.71 | MAPT (0.43) | MAPTRAB9AALDH1A1NPC1KMT2A | |
| SCHEMBL4026644 | 0.71 | ABCG2 (0.49) | MAPTRAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL6994738 | 0.71 | MAPT (0.69) | GAAMAPTRAB9AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060052368-A1 | Aryl-substituted diazabicycloalkanes as nicotinic acetylcholine agonists | ASTRAZENECA AB (SE) | 2006-03-09 | — | — | US | claimed |
| EP-1539764-B1 | ARYL-SUBSTITUTED DIAZABICYCLOALKANES AS NICOTINIC ACETYLCHOLINE AGONISTS. | ASTRAZENECA AB (SE) | 2009-04-29 | — | — | EP | disclosed |
| US-20060052368-A1 | Aryl-substituted diazabicycloalkanes as nicotinic acetylcholine agonists | ASTRAZENECA AB (SE) | 2006-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052368-A1 | Aryl-substituted diazabicycloalkanes as nicotinic acetylcholine agonists | CHRNA7, CHRNB1, CHRNA1 | GAA 2853/4885MAPT 3363/4885RAB9A 1223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.