Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.77 |
| ▸ | RORC | P51449 | 2/20 | 0.52 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4026641 | 0.87 | ESR1 (1.00) | ESR1RORCNR1H2NR1H3ESR2 | |
| SCHEMBL4032768 | 0.85 | ESR1 (0.77) | ESR1RORCNR1H2NR1H3ESR2 | |
| SCHEMBL4035132 | 0.85 | ESR1 (0.56) | ESR1RORCNR1H2NR1H3ALDH1A1 | |
| SCHEMBL4031338 | 0.83 | ESR1 (0.75) | ESR1RORCALDH1A1PDE4APDE4B | |
| SCHEMBL4028196 | 0.82 | ESR1 (0.73) | ESR1RORCNR1H2NR1H3ESR2 | |
| SCHEMBL4027587 | 0.80 | ESR1 (0.53) | ESR1RORCNR1H2NR1H3ESR2 | |
| SCHEMBL4026862 | 0.79 | F2RL3 (0.56) | ESR1RORCALDH1A1PDE4APDE4B | |
| SCHEMBL4031391 | 0.74 | PDE5A (0.47) | ESR1RORCALDH1A1PDE4APDE4B | |
| SCHEMBL4030028 | 0.73 | ESR1 (0.47) | ESR1RORCALDH1A1PDE4APDE4B | |
| SCHEMBL4028787 | 0.73 | ESR1 (0.47) | ESR1RORCALDH1A1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542976-B1 | SUBSTITUTED 4-(INDAZOL-3-YL)PHENOLS AS ESTROGEN RECEPTOR (ER) LIGANDS AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES | WYETH CORP (US) | 2009-02-04 | — | — | EP | disclosed |
| US-20070225349-A1 | Substituted 4-(Indazol-3-yl)phenols | WYETH (US) | 2007-09-27 | — | — | US | disclosed |
| US-7241791-B2 | Substituted 4-(indazol-3-yl)phenols | WYETH (US) | 2007-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225349-A1 | Substituted 4-(Indazol-3-yl)phenols | INSR, TNNI3, INSRR | ESR1 1028/4885RORC 142/4885NR1H2 368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.