Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPX4 | P36969 | 2/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | DRD1 | P21728 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HPN | P05981 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3298446 | 0.94 | GPX4 (0.34) | GPX4SLC6A9CYP2D6CYP19A1KCNH2 | |
| SCHEMBL3297618 | 0.94 | GPX4 (0.34) | GPX4SLC6A9CYP2D6CYP19A1CACNA2D1 | |
| SCHEMBL3299155 | 0.94 | GPX4 (0.34) | GPX4SLC6A9CYP2D6CYP19A1KCNH2 | |
| SCHEMBL3295171 | 0.93 | HSD17B10 (0.34) | GPX4SLC6A9CYP2D6CYP19A1 | |
| SCHEMBL7646797 | 0.92 | CNR1 (0.39) | CNR1CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL7653080 | 0.90 | FFAR2 (0.34) | CYP2D6CYP3A4CHRM2ADRA2ACHRM1 | |
| SCHEMBL7650011 | 0.90 | FFAR2 (0.34) | CYP2D6CYP3A4CHRM2ADRA2ACHRM1 | |
| SCHEMBL6647473 | 0.89 | TDP1 (0.35) | SLC6A9CYP2D6CHRM2ADRA2ACHRM1 | |
| SCHEMBL3298988 | 0.89 | — | — | |
| SCHEMBL6646348 | 0.89 | TDP1 (0.35) | SLC6A9CYP2D6CHRM2ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2012775-A1 | USE OF CBX CANNABINOID RECEPTOR MODULATORS AS POTASSIUM CHANNEL MODULATORS | Solvay Pharmaceuticals GmbH (DE) | 2009-01-14 | — | — | EP | claimed |
| WO-2007125049-A1 | USE OF CBX CANNABINOID RECEPTOR MODULATORS AS POTASSIUM CHANNEL MODULATORS | SOLVAY PHARMACEUTICALS GMBH (DE) | 2007-11-08 | — | — | WO | claimed |
| EP-1458413-B1 | PHARMACEUTICAL COMPOSITIONS BASED ON AZETIDINE DERIVATIVES | AVENTIS PHARMA SA (FR) | 2009-07-22 | — | — | EP | disclosed |
| EP-1263720-B1 | AZETIDINE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2009-06-03 | — | — | EP | disclosed |
| EP-1458413-A2 | PHARMACEUTICAL COMPOSITIONS BASED ON AZETIDINE DERIVATIVES | Aventis Pharma S.A. (FR) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003053431-A2 | PHARMACEUTICAL COMPOSITIONS BASED ON AZETIDINE DERIVATIVES | AVENTIS PHARMA S.A. (FR) | 2003-07-03 | — | — | WO | disclosed |