Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 14/20 | 0.68 |
| ▸ | CDK4 | P11802 | 6/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | CCND1 | P24385 | 4/20 | 0.47 |
| ▸ | CCND3 | P30281 | 4/20 | 0.47 |
| ▸ | CCND2 | P30279 | 3/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4193367 | 0.98 | CDK2 (0.71) | CDK2CDK4KCNH2CCND1CCND3 | |
| SCHEMBL4025419 | 0.95 | CDK2 (0.64) | CDK2CDK4KCNH2CCND1CCND3 | |
| SCHEMBL4023119 | 0.85 | CDK2 (0.52) | CDK2CDK4CCND1CCND3CCND2 | |
| SCHEMBL3549674 | 0.83 | CDK2 (0.69) | CDK2CDK4KCNH2CCND1CCND3 | |
| SCHEMBL4024196 | 0.83 | CDK2 (0.54) | CDK2CDK4CCND1CCND3CCND2 | |
| SCHEMBL5105343 | 0.80 | CDK2 (0.69) | CDK2CDK4KCNH2CCND1CCND3 | |
| SCHEMBL3547575 | 0.80 | KCNH2 (0.73) | CDK2CDK4KCNH2CCND1CCND3 | |
| SCHEMBL4028905 | 0.80 | CDK2 (0.65) | CDK2CDK4KCNH2CCND1CCND3 | |
| SCHEMBL1447563 | 0.80 | CDK2 (0.72) | CDK2KCNH2CDK1 | |
| SCHEMBL4262997 | 0.80 | CDK2 (0.60) | CDK2CDK4KCNH2CCND1CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485375-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2009-06-17 | — | — | EP | disclosed |
| US-7485638-B2 | Pyrimidine compounds | ASTRAZENECA AB (SE) | 2009-02-03 | — | — | US | disclosed |
| US-20050256311-A1 | Pyrimidine compounds | ASTRAZENECA AB (SE) | 2005-11-17 | — | — | US | disclosed |
| EP-1485375-A1 | PYRIMIDINE COMPOUNDS | AstraZeneca AB (SE) | 2004-12-15 | — | — | EP | disclosed |
| WO-2003076435-A1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256311-A1 | Pyrimidine compounds | TYMP, TYMS, CCNT1 | CDK2 24/4885CDK4 48/4885KCNH2 4329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.