Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.71 |
| ▸ | CDK4 | P11802 | 6/20 | 0.50 |
| ▸ | CCND1 | P24385 | 4/20 | 0.50 |
| ▸ | CCND2 | P30279 | 3/20 | 0.50 |
| ▸ | CCND3 | P30281 | 3/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030132 | 0.98 | CDK2 (0.68) | CDK2CDK4CCND1CCND2CCND3 | |
| SCHEMBL4025419 | 0.95 | CDK2 (0.64) | CDK2CDK4CCND1CCND3CCNA2 | |
| SCHEMBL4024196 | 0.85 | CDK2 (0.54) | CDK2CDK4CCND1CCND2CCND3 | |
| SCHEMBL4023119 | 0.83 | CDK2 (0.52) | CDK2CDK4CCND1CCND2CCND3 | |
| SCHEMBL4028905 | 0.82 | CDK2 (0.65) | CDK2CDK4CCND1CCND3CCNA2 | |
| SCHEMBL3549674 | 0.81 | CDK2 (0.69) | CDK2CDK4CCND1CCND2CCND3 | |
| SCHEMBL5105343 | 0.80 | CDK2 (0.69) | CDK2CDK4CCND1CCND3CCNA2 | |
| SCHEMBL1447876 | 0.80 | CDK2 (0.73) | CDK2KCNH2 | |
| SCHEMBL23752490 | 0.78 | CDK2 (0.66) | CDK2CDK4CCND1CCND3CCNA2 | |
| SCHEMBL3547575 | 0.78 | KCNH2 (0.73) | CDK2CDK4CCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485375-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2009-06-17 | — | — | EP | disclosed |