Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethyl Acetate SCHEMBL28207223 | 0.84 | ALDH1A1 (0.52) | ALDH1A1HSD17B10LMNASMN1; SMN2MAPT | |
| SCHEMBL11459101 | 0.81 | ALDH1A1 (0.42) | ALDH1A1HSD17B10LMNASMN1; SMN2MAPT | |
| Ethyl Acetate SCHEMBL27923714 | 0.81 | ALDH1A1 (0.52) | ALDH1A1HSD17B10LMNASMN1; SMN2MAPT | |
| Ethyl Acetate SCHEMBL27923708 | 0.81 | HSD17B10 (0.51) | ALDH1A1HSD17B10LMNASMN1; SMN2MAPT | |
| Thiophene Carboxylic Acid SCHEMBL27556383 | 0.79 | DAO (0.63) | ALDH1A1HSD17B10LMNASMN1; SMN2MAPT | |
| Ethyl Acetate SCHEMBL27923721 | 0.79 | HSD17B10 (0.50) | ALDH1A1HSD17B10LMNASMN1; SMN2MAPT | |
| Ethyl Acetate SCHEMBL28207231 | 0.79 | ALDH1A1 (0.47) | ALDH1A1HSD17B10LMNASMN1; SMN2MAPT | |
| Ethyl Acetate SCHEMBL27942738 | 0.79 | ALDH1A1 (0.47) | ALDH1A1HSD17B10LMNASMN1; SMN2MAPT | |
| Acetic Acid SCHEMBL4033823 | 0.78 | DAO (0.48) | ALDH1A1HSD17B10LMNASMN1; SMN2MAPT | |
| Ethyl Acetate SCHEMBL27942737 | 0.78 | HSD17B10 (0.49) | ALDH1A1HSD17B10LMNASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379240-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2009-04-08 | — | — | EP | disclosed |
| US-20060247280-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2006-11-02 | — | — | US | disclosed |
| EP-1379240-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002078696-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060247280-A1 | Compounds and methods | METAP2, DNPEP, METAP1 | ALDH1A1 1820/4885HSD17B10 2315/4885LMNA 4627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.