Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | PDE8B | O95263 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 7/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | IL1B | P01584 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1881122 | 0.88 | HTT (0.48) | KDM1APDE8BOPRD1PARP1ALDH1A1 | |
| SCHEMBL14373687 | 0.85 | KDM1A (0.42) | KDM1APDE8BOPRD1PARP1UCHL1 | |
| SCHEMBL834020 | 0.84 | OPRD1 (0.43) | KDM1AOPRD1ALOX5APFEN1PARP1 | |
| SCHEMBL27773040 | 0.82 | PARP1 (0.41) | PARP1ALDH1A1PARP2 | |
| SCHEMBL27773112 | 0.82 | CRBN (0.43) | KDM1APARP1UCHL1PARP2 | |
| SCHEMBL4031169 | 0.79 | NR1I2 (0.50) | KDM1AOPRD1ALDH1A1 | |
| SCHEMBL4564594 | 0.77 | KDM1A (0.37) | KDM1APDE8BOPRD1UCHL1ALDH1A1 | |
| SCHEMBL4200981 | 0.77 | NR1I2 (0.48) | KDM1AOPRD1ALDH1A1 | |
| SCHEMBL18793943 | 0.74 | FPR2 (0.43) | KDM1APDE8BOPRD1ALOX5APFEN1 | |
| SCHEMBL3008441 | 0.73 | PARP1 (0.45) | KDM1APDE8BOPRD1ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029535-A1 | ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER | AstraZeneca AB (SE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007139464-A1 | ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |
| WO-2007139464-A1 | ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |