Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 7/20 | 0.49 |
| ▸ | TTR | P02766 | 2/20 | 0.49 |
| ▸ | PYGL | P06737 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | RXRG | P48443 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24959789 | 0.86 | KMO (0.47) | KMOMRGPRX4 | |
| SCHEMBL4283750 | 0.86 | TSHR (0.53) | KMOTSHRMRGPRX4TTRPYGL | |
| SCHEMBL9526138 | 0.86 | KMO (0.47) | KMOMRGPRX4 | |
| SCHEMBL1109099 | 0.85 | SLC6A2 (0.48) | KMOMRGPRX4ALPL | |
| SCHEMBL9526240 | 0.85 | ESRRA (0.50) | KMOMRGPRX4 | |
| SCHEMBL3367612 | 0.84 | RXRA (0.54) | TSHRMRGPRX4TTRPYGLRXRA | |
| Hydrochloric Acid SCHEMBL11862687 | 0.83 | TSHR (0.53) | TSHRMRGPRX4TTRRXRARXRB | |
| SCHEMBL15543397 | 0.82 | SCN9A (0.47) | KMOMRGPRX4TTRPYGL | |
| SCHEMBL9145702 | 0.82 | TTR (0.46) | KMOTSHRMRGPRX4TTRRXRA | |
| SCHEMBL9578550 | 0.82 | TTR (0.46) | KMOTSHRMRGPRX4TTRRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115340536-B | Amide compound containing 1,2, 4-oxadiazole and salt, preparation method and application thereof | 华东理工大学 | 2024-12-10 | — | — | CN | disclosed |
| EP-3774800-B1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICALS CO (JP) | 2024-11-13 | — | — | EP | disclosed |
| US-11702419-B2 | Heterocyclic compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-07-18 | — | — | US | disclosed |
| WO-2023288253-A1 | SMALL MOLECULES INHIBITORS OF CYCLIC GMP-AMP SYNTHASE (CGAS) | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-01-19 | — | — | WO | disclosed |
| CN-115340536-A | Amide compound containing 1,2, 4-oxadiazole and salt thereof, preparation method and application | 华东理工大学 | 2022-11-15 | — | — | CN | disclosed |
| US-20210332053-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-10-28 | — | — | US | disclosed |
| EP-3774800-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2021-02-17 | — | — | EP | disclosed |
| CN-111936495-A | Heterocyclic compounds and their use | 武田药品工业株式会社 | 2020-11-13 | — | — | CN | disclosed |
| US-10807987-B2 | Heterocyclic compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-10-20 | — | — | US | disclosed |
| CN-107428683-B | Heterocyclic substituted N-sulfonyl benzamide derivative, preparation method and medical application thereof | 上海海雁医药科技有限公司 | 2020-06-02 | — | — | CN | disclosed |
| WO-2003087045-A1 | NOVEL METHOXYBENZAMIDE COMPOUNDS FOR USE IN MCH RECEPTOR RELATED DISORDERS | 7TM PHARMA A/S (DK) | 2003-10-23 | — | — | WO | disclosed |
| US-20020045551-A1 | 4-benzoyl isoxazoles derivatives and their use as herbicides | MUSIL TIBOR (GB) | 2002-04-18 | — | — | US | disclosed |
| US-6323155-B1 | EXCELLENT LEVEL OF HERBICIDAL ACTIVITY TOGETHER WITH CROP TOLERANCE | RHONE-POULENC AGRICULTURE LIMITED (GB) | 2001-11-27 | — | — | US | disclosed |
| EP-0743938-B1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 1999-04-21 | — | — | EP | disclosed |
| EP-0674629-B1 | 4-BENZOYL ISOXAZOLES DERIVATIVES AND THEIR USE AS HERBICIDES | RHONE POULENC AGRICULTURE (GB) | 1998-07-08 | — | — | EP | disclosed |
| EP-0743938-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-27 | — | — | EP | disclosed |
| EP-0674629-A1 | 4-BENZOYL ISOXAZOLES DERIVATIVES AND THEIR USE AS HERBICIDES | RHONE-POULENC AGRICULTURE LTD. (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1995021817-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-08-17 | — | — | WO | disclosed |
| WO-1994014782-A1 | 4-BENZOYL ISOXAZOLES DERIVATIVES AND THEIR USE AS HERBICIDES | RHONE-POULENC AGRICULTURE LTD. (GB) | 1994-07-07 | — | — | WO | disclosed |
| US-4914123-A | Acyloxythiophene derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1990-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10807987-B2 | Heterocyclic compound and use thereof | GRIN2B, GRIN2A, GRIN2C | KMO 552/4885TSHR 3089/4885MRGPRX4 641/4885 |
| US-20020045551-A1 | 4-benzoyl isoxazoles derivatives and their use as herbicides | CBR3, CBR1, GLRA3 | KMO 1498/4885TSHR 174/4885MRGPRX4 992/4885 |
| US-20210332053-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | GRIN2B, GRIN2A, GRIN2C | KMO 552/4885TSHR 3089/4885MRGPRX4 641/4885 |
| US-11702419-B2 | Heterocyclic compound and use thereof | GRIN2B, GRIN2A, GRIN2C | KMO 552/4885TSHR 3089/4885MRGPRX4 641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.