Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 4/20 | 0.45 |
| ▸ | CDK9 | P50750 | 4/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.38 |
| ▸ | CDC7 | O00311 | 6/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4026620 | 0.90 | CCNT1 (0.44) | CCNT1CDK9DYRK3DYRK1ADYRK2 | |
| SCHEMBL5102065 | 0.89 | CCNT1 (0.44) | CCNT1CDK9DYRK3DYRK1ADYRK2 | |
| SCHEMBL4024211 | 0.83 | CCNT1 (0.48) | CCNT1CDK9DYRK3DYRK1ADYRK2 | |
| SCHEMBL6595871 | 0.78 | DYRK1A (0.45) | CCNT1CDK9DYRK3DYRK1ADYRK2 | |
| SCHEMBL5258483 | 0.75 | CDC7 (0.46) | CCNT1CDK9DYRK3DYRK1ADYRK2 | |
| SCHEMBL4022085 | 0.71 | CDC7 (0.51) | CCNT1CDK9DYRK3DYRK1ADYRK2 | |
| SCHEMBL6595714 | 0.67 | CDK2 (0.52) | CCNT1CDK9DYRK3DYRK1ADYRK2 | |
| SCHEMBL1447550 | 0.66 | CDC7 (0.46) | CCNT1CDK9DYRK3DYRK1ADYRK2 | |
| SCHEMBL6596348 | 0.65 | DYRK1A (0.46) | CCNT1CDK9DYRK3DYRK1ADYRK2 | |
| SCHEMBL4030180 | 0.65 | CDK2 (0.46) | CCNT1CDK9DYRK3DYRK1ADYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485375-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2009-06-17 | — | — | EP | disclosed |