Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HMGCR | P04035 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034681 | 0.75 | GAA (0.41) | CYP2C19TP53POLBCYP2C9HSD17B10 | |
| SCHEMBL25659032 | 0.74 | CYP2D6 (0.38) | CYP2D6CYP2C19HIF1AGMNNTP53 | |
| SCHEMBL2223767 | 0.72 | — | — | |
| SCHEMBL8725908 | 0.72 | CYP2D6 (0.45) | FFAR3CYP2D6CYP2C19HIF1AGMNN | |
| SCHEMBL6701234 | 0.72 | CYP2D6 (0.45) | FFAR3CYP2D6CYP2C19HIF1AGMNN | |
| SCHEMBL14549079 | 0.70 | — | — | |
| SCHEMBL26036469 | 0.70 | DGAT1 (0.39) | CYP2D6CYP2C19HIF1AALDH1A1HMGCR | |
| SCHEMBL9174852 | 0.69 | CYP2D6 (0.41) | FFAR3CYP2D6CYP2C19HIF1AGMNN | |
| SCHEMBL13130591 | 0.68 | HSD17B10 (0.38) | FFAR3CYP2D6CYP2C19HIF1AGMNN | |
| SCHEMBL13129910 | 0.68 | CYP2D6 (0.42) | FFAR3CYP2D6CYP2C19HIF1AGMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687301-B1 | THIAEPOTHILONE FOR TREATING CANCEROUS DISEASES | LEIBNIZ INST FUER PFLANZENBIOC (DE) | 2009-05-13 | — | — | EP | claimed |
| EP-1687301-B1 | THIAEPOTHILONE FOR TREATING CANCEROUS DISEASES | LEIBNIZ INST FUER PFLANZENBIOC (DE) | 2009-05-13 | — | — | EP | disclosed |
| EP-1687301-B1 | THIAEPOTHILONE FOR TREATING CANCEROUS DISEASES | LEIBNIZ INST FUER PFLANZENBIOC (DE) | 2009-05-13 | — | — | EP | disclosed |
| US-7381743-B2 | Macrocycles for the treatment of cancer | LEIBNIZ-INSTITUT FUER PFLANZENBIOCHEMIE (IPB) (DE) | 2008-06-03 | — | — | US | disclosed |
| US-7381743-B2 | Macrocycles for the treatment of cancer | LEIBNIZ-INSTITUT FUER PFLANZENBIOCHEMIE (IPB) (DE) | 2008-06-03 | — | — | US | disclosed |
| US-7381743-B2 | Macrocycles for the treatment of cancer | LEIBNIZ-INSTITUT FUER PFLANZENBIOCHEMIE (IPB) (DE) | 2008-06-03 | — | — | US | disclosed |
| US-20070105905-A1 | Novel macrocycles for the treatment of cancer | LEIBNIZ-INSTITUT FUER PFLANZENBIOCHEMIE (IPB) (DE) | 2007-05-10 | — | — | US | disclosed |
| US-20070105905-A1 | Novel macrocycles for the treatment of cancer | LEIBNIZ-INSTITUT FUER PFLANZENBIOCHEMIE (IPB) (DE) | 2007-05-10 | — | — | US | disclosed |
| US-20070105905-A1 | Novel macrocycles for the treatment of cancer | LEIBNIZ-INSTITUT FUER PFLANZENBIOCHEMIE (IPB) (DE) | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105905-A1 | Novel macrocycles for the treatment of cancer | HCCS, FOLR1, AURKAIP1 | FFAR3 3736/4885CYP2D6 963/4885CYP2C19 1061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.