SCHEMBL4031752

SCHEMBL4031752

CC1(C)C(=O)NC(=S)N1c1ccc(Cl)c(C(F)(F)F)c1

nearest known ligand 0.59

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
AR P10275 10/20 0.59
NOTUM Q6P988 8/20 0.42
ADAMTS5 Q9UNA0 1/20 0.39
PRF1 P14222 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4032141 0.81 AR (0.61) AR
SCHEMBL4031754 0.79 AR (0.79) AR
SCHEMBL11568388 0.78 AR (0.62) ARNOTUMADAMTS5
SCHEMBL11079218 0.74 AR (1.00) AR
SCHEMBL8004308 0.74 AR (0.60) ARNOTUM
SCHEMBL11087769 0.72 AR (0.76) ARNOTUM
SCHEMBL17082984 0.70 SMN1; SMN2 (0.44) AR
SCHEMBL6826801 0.69 NOTUM (0.48) ARNOTUM
SCHEMBL332312 0.68 AR (0.58) ARNOTUM
SCHEMBL4023707 0.68 AR (0.73) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009097996-A1 USE OF SUBSTITUTED PHENYLIMIDAZOLIDINES FOR PRODUCING MEDICAMENTS FOR TREATING METABOLIC SYNDROME SANOFI-AVENTIS (FR) 2009-08-13 WO disclosed