Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.35 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.35 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.35 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034111 | 0.87 | BRD4 (0.37) | NPC1RAB9AMEN1KMT2ALPAR1 | |
| SCHEMBL4034159 | 0.87 | LPAR1 (0.44) | NPC1RAB9AMEN1KMT2ALPAR1 | |
| SCHEMBL4034800 | 0.86 | TRPV1 (0.38) | LPAR1LPAR3NPSR1IP6K1IP6K3 | |
| SCHEMBL4028121 | 0.85 | LPAR1 (0.44) | NPC1RAB9AMEN1KMT2ALPAR1 | |
| SCHEMBL4030912 | 0.85 | HDAC3 (0.40) | LPAR1LPAR3TSHRNPSR1L3MBTL1 | |
| SCHEMBL4034108 | 0.81 | LPAR1 (0.44) | MEN1KMT2ALPAR1LPAR3ALDH1A1 | |
| SCHEMBL4028274 | 0.79 | LPAR1 (0.37) | NPC1MEN1KMT2ALPAR1LPAR3 | |
| SCHEMBL4032476 | 0.79 | LPAR1 (0.43) | MEN1KMT2ALPAR1LPAR3TSHR | |
| SCHEMBL15437576 | 0.79 | LPAR1 (0.43) | MEN1KMT2ALPAR1LPAR3ALDH1A1 | |
| SCHEMBL4032913 | 0.77 | LPAR1 (0.42) | NPC1RAB9AMEN1KMT2ALPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |