Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.37 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.37 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.34 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.33 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.33 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030980 | 0.90 | IP6K1 (0.38) | TRPV1IP6K1IP6K3IP6K2SERPINE1 | |
| SCHEMBL4030024 | 0.89 | LPAR1 (0.42) | TRPV1IP6K1IP6K3IP6K2SERPINE1 | |
| SCHEMBL4030691 | 0.88 | LPAR1 (0.41) | TRPV1IP6K1IP6K3IP6K2SERPINE1 | |
| SCHEMBL4031825 | 0.86 | NPC1 (0.38) | IP6K1IP6K3IP6K2NPSR1TP53 | |
| SCHEMBL4030912 | 0.80 | HDAC3 (0.40) | NPSR1PPARGPPARDPPARALPAR1 | |
| SCHEMBL4034287 | 0.79 | SLC16A3 (0.37) | IP6K1IP6K3IP6K2LPAR1LPAR3 | |
| SCHEMBL4033894 | 0.77 | LPAR1 (0.44) | NPSR1MAPTLPAR1LPAR3GPBAR1 | |
| SCHEMBL4034111 | 0.76 | BRD4 (0.37) | IP6K1IP6K3IP6K2NPSR1TP53 | |
| SCHEMBL4029352 | 0.75 | LPAR1 (0.57) | TRPV1IP6K1IP6K3IP6K2NPSR1 | |
| SCHEMBL4029347 | 0.75 | LPAR1 (0.57) | TRPV1IP6K1IP6K3IP6K2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |