Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.42 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.42 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 2/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034108 | 0.93 | LPAR1 (0.44) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL4034159 | 0.90 | LPAR1 (0.44) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL4032476 | 0.88 | LPAR1 (0.43) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL15437576 | 0.88 | LPAR1 (0.43) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL4032395 | 0.88 | LPAR1 (0.40) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL4034499 | 0.87 | LPAR1 (0.48) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL4033894 | 0.87 | LPAR1 (0.44) | LPAR1LPAR3LPAR2MAPTCTSA | |
| SCHEMBL4036790 | 0.86 | TRPA1 (0.46) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL4031584 | 0.85 | LPAR1 (0.43) | LPAR1LPAR3MAPTKDM4EMAPK1 | |
| SCHEMBL4028781 | 0.85 | LPAR1 (0.42) | LPAR1LPAR3LPAR2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |