Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 14/20 | 0.57 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | LIFR | P42702 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2772480 | 0.91 | NR1H4 (0.60) | NR1H4MRGPRX4LIFRNR4A2PLA2G4A | |
| SCHEMBL2771465 | 0.89 | NR1H4 (0.64) | NR1H4MRGPRX4LIFRNR4A2 | |
| SCHEMBL4042349 | 0.87 | NR1H4 (0.52) | NR1H4MRGPRX4FFAR1 | |
| SCHEMBL2770890 | 0.87 | NR1H4 (0.64) | NR1H4MRGPRX4LIFRNR4A2 | |
| SCHEMBL2772758 | 0.85 | NR1H4 (0.60) | NR1H4MRGPRX4LIFR | |
| SCHEMBL2770317 | 0.85 | NR1H4 (0.68) | NR1H4MRGPRX4LIFRNR4A2 | |
| SCHEMBL2770824 | 0.84 | NR1H4 (0.59) | NR1H4MRGPRX4 | |
| SCHEMBL2787707 | 0.84 | NR1H4 (0.59) | NR1H4MRGPRX4NR4A2 | |
| SCHEMBL2770618 | 0.84 | NR1H4 (0.58) | NR1H4MRGPRX4LIFR | |
| SCHEMBL2772215 | 0.83 | NR1H4 (0.56) | NR1H4MRGPRX4LIFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-A1 | FXR AGONISTS | ELI LILLY AND COMPANY (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140183-A1 | FXR AGONISTS | ELI LILLY AND COMPANY (US) | 2007-12-06 | — | — | WO | disclosed |