Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 11/20 | 0.64 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.42 |
| ▸ | LIFR | P42702 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2772480 | 0.94 | NR1H4 (0.60) | NR1H4NR4A2MRGPRX4LIFRPPARA | |
| SCHEMBL2770317 | 0.93 | NR1H4 (0.68) | NR1H4NR4A2NPC1RAB9AMRGPRX4 | |
| SCHEMBL2771465 | 0.88 | NR1H4 (0.64) | NR1H4NR4A2NPC1RAB9AMRGPRX4 | |
| SCHEMBL2771389 | 0.87 | NR1H4 (0.54) | NR1H4MRGPRX4PPARAPPARG | |
| SCHEMBL2772849 | 0.87 | NR1H4 (0.54) | NR1H4MRGPRX4PPARAPPARG | |
| SCHEMBL2771248 | 0.87 | NR1H4 (0.66) | NR1H4NR4A2NPC1RAB9AMRGPRX4 | |
| SCHEMBL4031907 | 0.87 | NR1H4 (0.57) | NR1H4NR4A2MRGPRX4LIFR | |
| SCHEMBL2771809 | 0.87 | NR1H4 (0.54) | NR1H4MRGPRX4PPARAPPARG | |
| SCHEMBL2771757 | 0.86 | NR1H4 (0.65) | NR1H4NR4A2NPC1RAB9AMRGPRX4 | |
| SCHEMBL2772157 | 0.86 | NR1H4 (0.53) | NR1H4NR4A2MRGPRX4NR4A1NR4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |