Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 11/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032850 | 0.87 | NR1H4 (0.52) | NR1H4NR1H2NR1H3MRGPRX4GCGR | |
| SCHEMBL4031907 | 0.87 | NR1H4 (0.57) | NR1H4MRGPRX4FFAR1 | |
| SCHEMBL2772298 | 0.86 | NR1H4 (0.54) | NR1H4NR1H2NR1H3MRGPRX4NPBWR1 | |
| SCHEMBL2770907 | 0.84 | NR1H4 (0.52) | NR1H4NR1H2NR1H3MRGPRX4GCGR | |
| SCHEMBL2770890 | 0.82 | NR1H4 (0.64) | NR1H4MRGPRX4PPARGPPARA | |
| SCHEMBL2772480 | 0.81 | NR1H4 (0.60) | NR1H4MRGPRX4PPARGPPARA | |
| SCHEMBL2770295 | 0.81 | NR1H4 (0.55) | NR1H4MRGPRX4NPBWR1MCHR1PPARD | |
| SCHEMBL4036782 | 0.80 | NR1H4 (0.61) | NR1H4MRGPRX4 | |
| SCHEMBL2770317 | 0.80 | NR1H4 (0.68) | NR1H4MRGPRX4 | |
| SCHEMBL2773824 | 0.79 | NR1H4 (0.56) | NR1H4MRGPRX4NPBWR1MCHR1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-A1 | FXR AGONISTS | ELI LILLY AND COMPANY (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140183-A1 | FXR AGONISTS | ELI LILLY AND COMPANY (US) | 2007-12-06 | — | — | WO | disclosed |