Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | PKM | P14618 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31526266 | 0.87 | PTGS1 (0.72) | ALDH1A1KDM4EPOLBLMNAHPGD | |
| SCHEMBL14840641 | 0.87 | ALDH1A1 (0.60) | ALDH1A1PKMKDM4EPOLBLMNA | |
| SCHEMBL31526126 | 0.86 | ALDH1A1 (0.59) | ALDH1A1PKMKDM4EPOLBLMNA | |
| SCHEMBL8243211 | 0.86 | ALDH1A1 (0.64) | ALDH1A1PKMKDM4EPOLBLMNA | |
| SCHEMBL16502243 | 0.85 | PTGS1 (0.73) | ALDH1A1PKMKDM4ELMNAHPGD | |
| SCHEMBL31526118 | 0.85 | POLB (0.61) | ALDH1A1PKMKDM4EPOLBHPGD | |
| SCHEMBL6166566 | 0.84 | ALDH1A1 (0.59) | ALDH1A1PKMKDM4EPOLBLMNA | |
| SCHEMBL768777 | 0.83 | PTGS1 (0.51) | ALDH1A1PKMKDM4EPOLBLMNA | |
| SCHEMBL13438 | 0.82 | PTGS1 (0.69) | ALDH1A1PKMKDM4ELMNASMN1; SMN2 | |
| SCHEMBL31526330 | 0.82 | ALDH1A1 (0.57) | ALDH1A1PKMKDM4EPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | disclosed |
| US-6964975-B2 | Isoxazole and thiazole compounds and use thereof as medicine | KIRIN BEER KABUSHIKI KAISHA (JP) | 2005-11-15 | — | — | US | disclosed |
| US-20030114505-A1 | Novel isoxazole and thiazole compounds and use thereof as drugs | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2003-06-19 | — | — | US | disclosed |
| EP-1258484-A1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KIRIN BEER KABUSHIKI KAISHA (JP) | 2002-11-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114505-A1 | Novel isoxazole and thiazole compounds and use thereof as drugs | LPAR3, LPAR1, LPAR4 | ALDH1A1 1093/4885PKM 1633/4885KDM4E 2904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.