Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 4/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2772320 | 0.81 | DHODH (0.39) | GABRA1GABRG2GABRB3MEN1KMT2A | |
| SCHEMBL2773215 | 0.70 | GABRA1 (0.39) | GABRA1GABRG2GABRB3 | |
| SCHEMBL2770799 | 0.68 | TRPA1 (0.38) | MEN1KMT2A | |
| SCHEMBL2772785 | 0.68 | CCR1 (0.34) | GABRA1GABRG2GABRB3 | |
| SCHEMBL3774518 | 0.68 | NR1H4 (0.39) | GABRA1GABRG2GABRB3 | |
| SCHEMBL1095989 | 0.67 | NR1H4 (0.46) | GABRA1GABRG2GABRB3MEN1KMT2A | |
| SCHEMBL10247671 | 0.67 | GABRA1 (0.40) | FFAR1FFAR4GABRA1GABRG2GABRB3 | |
| SCHEMBL2775151 | 0.62 | NR1H4 (0.37) | GABRA1GABRG2GABRB3 | |
| SCHEMBL28802335 | 0.61 | APOBEC3G (0.59) | FFAR1FFAR4NTRK1PKM | |
| SCHEMBL12340468 | 0.60 | NR4A3 (0.56) | MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-A1 | FXR AGONISTS | ELI LILLY AND COMPANY (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140183-A1 | FXR AGONISTS | ELI LILLY AND COMPANY (US) | 2007-12-06 | — | — | WO | disclosed |