SCHEMBL4032125

SCHEMBL4032125

Cc1cc(Cl)cnc1CNCC(C)c1ccccn1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CXCR4 P61073 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.36
PTGFR P43088 1/20 0.34
CHRM2 P08172 2/20 0.33
CHRM5 P08912 2/20 0.33
CHRM1 P11229 2/20 0.33
ADRA2B P18089 2/20 0.33
SLC6A2 P23975 2/20 0.33
HRH2 P25021 2/20 0.33
HTR2A P28223 2/20 0.33
SLC6A4 P31645 2/20 0.33
HRH1 P35367 2/20 0.33
SLC6A3 Q01959 2/20 0.33
KCNH2 Q12809 2/20 0.33
HRH3 Q9Y5N1 2/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
TSHR P16473 1/20 0.33
NFKB1 P19838 1/20 0.33
THPO P40225 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4033313 0.88 CXCR4 (0.49) CXCR4PTGFRSLC6A2SLC6A4SLC6A3
SCHEMBL4032120 0.73 RAB9A (0.39) SMN1; SMN2CYP2D6CYP2C9TSHRMEN1
SCHEMBL2085376 0.70 ANO1 (0.38) SMN1; SMN2L3MBTL1MEN1KMT2AOPRK1
SCHEMBL11175372 0.67 TAAR1 (0.50) PTGFRCHRM2CHRM1SLC6A2SLC6A4
Ammonia Solution, Strong SCHEMBL5574435 0.66 CXCR4 (0.50) CXCR4CHRM2CHRM5CHRM1TSHR
SCHEMBL10938888 0.64 KCNA5 (0.50) CHRM2CHRM5CHRM1ADRA2BSLC6A2
SCHEMBL8191763 0.63 TSHR (0.41) SMN1; SMN2PTGFRCHRM2SLC6A2SLC6A4
SCHEMBL2081855 0.62 CXCR4 (0.47) CXCR4SLC6A2SLC6A4SLC6A3KCNH2
SCHEMBL13638230 0.62 KCNA5 (0.52) SMN1; SMN2CHRM2SLC6A2SLC6A4SLC6A3
SCHEMBL13862942 0.62 KCNA5 (0.52) SMN1; SMN2CHRM2SLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1613613-A4 CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS ANORMED INC (CA) 2009-03-25 EP disclosed
EP-1613613-A2 CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS ANORMED INC. (CA) 2006-01-11 EP disclosed
WO-2004091518-A2 CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS ANORMED INC. (CA) 2004-10-28 WO disclosed