SCHEMBL4032240

SCHEMBL4032240

COc1cccc(OC)c1CNC(=O)C1CCNCC1

nearest known ligand 0.62

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.62
SMN1; SMN2 Q16637 1/20 0.62
HPGD P15428 2/20 0.56
MTNR1A P48039 1/20 0.56
MTNR1B P49286 1/20 0.56
EPHX2 P34913 1/20 0.53
CYP1A2 P05177 1/20 0.48
CYP2C19 P33261 1/20 0.48
NPC1 O15118 1/20 0.48
PKM P14618 1/20 0.48
RAB9A P51151 1/20 0.48
TSHR P16473 1/20 0.48
CHRM1 P11229 1/20 0.48
CHRM3 P20309 1/20 0.48
KMT2A Q03164 1/20 0.47
CD274 Q9NZQ7 2/20 0.47
ACHE P22303 1/20 0.45
BACE1 P56817 1/20 0.45
ROCK2 O75116 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31290835 0.86 ALDH1A1 (0.66) ALDH1A1SMN1; SMN2HPGDMTNR1AMTNR1B
SCHEMBL11403472 0.85 HPGD (0.78) ALDH1A1SMN1; SMN2HPGDEPHX2CYP1A2
Trifluoroacetic Acid SCHEMBL30164323 0.79 EPHX2 (0.57) ALDH1A1SMN1; SMN2HPGDMTNR1AMTNR1B
SCHEMBL13746152 0.79 ALDH1A1 (0.74) ALDH1A1SMN1; SMN2EPHX2PKMTSHR
SCHEMBL11399325 0.78 EPHX2 (0.71) ALDH1A1SMN1; SMN2HPGDEPHX2TSHR
SCHEMBL17048481 0.78 HPGD (0.70) ALDH1A1SMN1; SMN2HPGDCYP1A2CYP2C19
SCHEMBL13745650 0.77 ALDH1A1 (1.00) ALDH1A1SMN1; SMN2EPHX2NPC1RAB9A
SCHEMBL16102804 0.76 ALDH1A1 (0.56) ALDH1A1SMN1; SMN2HPGDMTNR1AMTNR1B
SCHEMBL8132848 0.75 SMN1; SMN2 (0.74) ALDH1A1SMN1; SMN2HPGDPKMTSHR
SCHEMBL29361009 0.75 SMN1; SMN2 (0.74) ALDH1A1SMN1; SMN2HPGDPKMTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1501467-A4 HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION BRISTOL MYERS SQUIBB CO (US) 2009-08-19 EP disclosed
EP-1501467-A2 HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION Bristol-Myers Squibb Company (US) 2005-02-02 EP disclosed
WO-2003088908-A2 HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2003-10-30 WO disclosed