Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 12/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3109914 | 0.85 | GRIA2 (0.60) | GRIA2CYP1A2CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL3104592 | 0.85 | GRIA2 (0.63) | GRIA2CYP1A2CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL3103091 | 0.79 | GRIA2 (0.53) | GRIA2CYP1A2CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL3107408 | 0.79 | GRIA2 (0.77) | GRIA2CYP1A2CYP2D6PTGS2CYP2C19 | |
| SCHEMBL8039330 | 0.79 | PTGS2 (0.68) | PTGS2 | |
| SCHEMBL8023227 | 0.77 | PTGS2 (0.56) | PTGS2 | |
| SCHEMBL8037470 | 0.77 | PTGS2 (0.56) | PTGS2 | |
| SCHEMBL3132184 | 0.77 | GRIA2 (0.71) | GRIA2CYP1A2CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL4747751 | 0.73 | GRIA2 (0.67) | GRIA2CYP1A2CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL8023576 | 0.73 | PTGS2 (0.62) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051966-A2 | HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE | Pfizer Products Inc. (US) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008017932-A2 | HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE | PFIZER PRODUCTS INC. (US) | 2008-02-14 | — | — | WO | disclosed |