Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | CTSG | P08311 | 1/20 | 0.30 |
| ▸ | CTRC | Q99895 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5720325 | 0.90 | L3MBTL1 (0.35) | TP53GAACACNA1GCACNA1HCACNA1I | |
| SCHEMBL1830394 | 0.86 | L3MBTL1 (0.38) | GAACACNA1GCACNA1HCACNA1IL3MBTL1 | |
| SCHEMBL8671581 | 0.85 | L3MBTL1 (0.34) | TP53GAACACNA1GCACNA1HCACNA1I | |
| SCHEMBL8632992 | 0.80 | GAA (0.35) | TP53GAA | |
| SCHEMBL5720267 | 0.79 | GAA (0.48) | TP53GAACACNA1GCACNA1HCACNA1I | |
| SCHEMBL12821189 | 0.77 | GBA1 (0.43) | TP53GAAL3MBTL1 | |
| SCHEMBL10699214 | 0.77 | GBA1 (0.47) | TP53GAA | |
| SCHEMBL7246666 | 0.72 | ALOX5 (0.35) | CACNA1GCACNA1HCACNA1IL3MBTL1F2 | |
| SCHEMBL7238604 | 0.72 | F2 (0.32) | F2ELANECTSGCTRC | |
| SCHEMBL12821134 | 0.72 | L3MBTL1 (0.37) | TP53GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054408-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | Novartis Ag (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008127349-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | NOVARTIS AG (CH) | 2008-10-23 | — | — | WO | disclosed |
| EP-0718291-B1 | Method for the preparation of triazole compounds | CHUGAI PHARMACEUTICAL CO LTD (JP) | 1998-07-08 | — | — | EP | disclosed |
| US-5567825-A | Method for the preparation of a triazole compound | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1996-10-22 | — | — | US | disclosed |
| EP-0718291-A1 | Method for the preparation of triazole compounds | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1996-06-26 | — | — | EP | disclosed |