SCHEMBL4032722

SCHEMBL4032722

O=C1Cc2ccc(NC(=O)c3ccccc3NCc3ccnc(Br)c3)cc2N1

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KIT P10721 20/20 0.50
BRAF P15056 20/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4034613 0.93 JAK3 (0.52) KITBRAF
SCHEMBL4042743 0.88 KIT (0.53) KITBRAF
SCHEMBL4034820 0.87 JAK3 (0.46) KITBRAF
SCHEMBL4042753 0.86 KIT (0.49) KITBRAF
SCHEMBL4034696 0.81 JAK3 (0.47) KITBRAF
SCHEMBL4040683 0.81 JAK3 (0.54) KITBRAF
SCHEMBL6792344 0.80 RXFP1 (0.42) KITBRAF
SCHEMBL6542886 0.80 JAK3 (0.51) KITBRAF
SCHEMBL6543366 0.80 KIT (0.64) KITBRAF
SCHEMBL4036359 0.80 JAK3 (0.54) KITBRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1392680-B1 SELECTIVE ANTHRANILAMIDE PYRIDINE AMIDES AS INHIBITORS OF VEGFR-2 AND VEGFR-3 BAYER SCHERING PHARMA AG (DE) 2009-07-22 EP disclosed
US-20040254185-A1 Selective anthranilamide pyridine amides as inhibitors of vegfr-2 and vegfr-3 BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2004-12-16 US disclosed
CN-1518546-A Selective anthranilamide picolinamides as VEGRF-2 and VEGFR-3 inhibitors ���ֹɷݹ�˾ 2004-08-04 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040254185-A1 Selective anthranilamide pyridine amides as inhibitors of vegfr-2 and vegfr-3 FLT4, KDR, FLT1 KIT 34/4885BRAF 23/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.