⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036017 | 0.84 | OXTR (0.38) | — | |
| SCHEMBL6413770 | 0.81 | — | — | |
| SCHEMBL12763786 | 0.76 | POLB (0.38) | — | |
| SCHEMBL19281353 | 0.76 | OXTR (0.38) | — | |
| SCHEMBL22957177 | 0.76 | OXTR (0.38) | — | |
| SCHEMBL27625405 | 0.75 | CYP1A2 (0.44) | — | |
| SCHEMBL9601697 | 0.73 | OXTR (0.40) | — | |
| SCHEMBL14937937 | 0.73 | KCNN1 (0.50) | — | |
| SCHEMBL309844 | 0.73 | — | — | |
| SCHEMBL18861931 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2033962-A1 | Tetracyclic indolopyridines as EG5 inhibitors | 4SC AG (DE) | 2009-03-11 | — | — | EP | claimed |
| CN-109563092-B | 2-phenylimidazo [4,5-B ] pyridin-7-amine derivatives useful as inhibitors of the activity of the mammalian tyrosine kinase ROR1 | 坎塞拉有限公司 | 2021-09-14 | — | — | CN | disclosed |
| EP-2033962-A1 | Tetracyclic indolopyridines as EG5 inhibitors | 4SC AG (DE) | 2009-03-11 | — | — | EP | disclosed |