Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 15/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 8/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12714306 | 0.80 | PARP1 (0.50) | PARP1PARP2CRBNHTTLMNA | |
| SCHEMBL20214403 | 0.78 | HTT (0.58) | PARP1PARP2HTTLMNAALOX15 | |
| SCHEMBL12714369 | 0.78 | PARP1 (0.50) | PARP1PARP2CRBNHTTLMNA | |
| SCHEMBL4209630 | 0.77 | ACHE (0.43) | PARP1PARP2HTTLMNAADRA1D | |
| SCHEMBL4027209 | 0.77 | PARP1 (0.66) | PARP1PARP2HTTLMNA | |
| SCHEMBL12714324 | 0.77 | PARP1 (0.49) | PARP1PARP2CRBNHTTLMNA | |
| SCHEMBL29609402 | 0.77 | PARP1 (0.49) | PARP1PARP2CRBNHTTLMNA | |
| SCHEMBL12714375 | 0.77 | PARP1 (0.49) | PARP1PARP2CRBNHTTLMNA | |
| SCHEMBL12714359 | 0.77 | PARP1 (0.68) | PARP1PARP2CRBNHTTLMNA | |
| SCHEMBL12714329 | 0.77 | PARP1 (0.43) | PARP1PARP2CRBNHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029535-A1 | ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER | AstraZeneca AB (SE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007139464-A1 | ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |
| WO-2007139464-A1 | ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |