Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | PARP1 | P09874 | 14/20 | 0.52 |
| ▸ | PARP2 | Q9UGN5 | 8/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PREP | P48147 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29802795 | 0.79 | PARP1 (0.80) | HTTALOX15PARP1PARP2LMNA | |
| SCHEMBL17207994 | 0.79 | PARP1 (0.80) | HTTALOX15PARP1PARP2LMNA | |
| SCHEMBL4032899 | 0.78 | PARP1 (0.42) | HTTALOX15PARP1PARP2LMNA | |
| SCHEMBL833951 | 0.78 | PARP1 (0.78) | HTTALOX15PARP1PARP2LMNA | |
| SCHEMBL15730847 | 0.77 | PARP1 (0.65) | HTTALOX15PARP1PARP2PREP | |
| SCHEMBL1863347 | 0.77 | HTT (0.71) | HTTALOX15PARP1PARP2LMNA | |
| SCHEMBL29802830 | 0.77 | PARP1 (0.81) | HTTALOX15PARP1PARP2LMNA | |
| SCHEMBL835757 | 0.76 | PARP1 (0.74) | HTTALOX15PARP1PARP2LMNA | |
| SCHEMBL1865315 | 0.76 | HTT (0.86) | HTTALOX15PARP1PARP2KDM4E | |
| SCHEMBL17208008 | 0.76 | POLB (0.67) | HTTALOX15PARP1PARP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11208386-B2 | Inhibitors of protein arginine deiminases (PADs) and methods of preparation and use thereof | UNIVERSITY OF MASSACHUSETTS (US) | 2021-12-28 | — | — | US | disclosed |
| US-20200339518-A1 | INHIBITORS OF PROTEIN ARGININE DEIMINASES (PADS) AND METHODS OF PREPARATION AND USE THEREOF | UNIV MASSACHUSETTS (US) | 2020-10-29 | — | — | US | disclosed |
| WO-2018102262-A1 | INHIBITORS OF PROTEIN ARGININE DEIMINASES (PADS) AND METHODS OF PREPARATION AND USE THEREOF | UNIVERSITY OF MASSACHUSETTS (US) | 2018-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11208386-B2 | Inhibitors of protein arginine deiminases (PADs) and methods of preparation and use thereof | PADI2, PADI1, PADI4 | HTT 4217/4885ALOX15 1539/4885PARP1 605/4885 |
| US-20200339518-A1 | INHIBITORS OF PROTEIN ARGININE DEIMINASES (PADS) AND METHODS OF PREPARATION AND USE THEREOF | PADI2, PADI1, PADI4 | HTT 4217/4885ALOX15 1539/4885PARP1 605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.