Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 12/20 | 0.45 |
| ▸ | XIAP | P98170 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.38 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
| ▸ | IDH2 | P48735 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1789684 | 0.82 | PIK3CD (0.73) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL2073010 | 0.71 | PIK3CD (0.42) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL48707 | 0.70 | PIK3CD (0.59) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL5063157 | 0.68 | GPR52 (0.41) | PIK3CDPIK3CAPIK3CBPIK3CGXIAP | |
| SCHEMBL48602 | 0.68 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL1787124 | 0.68 | PIK3CD (0.73) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL1786067 | 0.68 | PIK3CD (0.85) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL1784035 | 0.68 | PIK3CD (0.63) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL5063159 | 0.68 | CCNT1 (0.43) | PIK3CACDK9 | |
| SCHEMBL5785803 | 0.68 | PIK3CG (0.70) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689391-B1 | 5-PHENYL-4-METHYL-THIAZOL-2-YL-AMINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3 KINASE ENZYMES (PI3) FOR THE TREATMENT OF INFLAMMATORY AIRWAY DISEASES | NOVARTIS AG (CH) | 2009-04-22 | — | — | EP | disclosed |