Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 11/20 | 1.00 |
| ▸ | PLK1 | P53350 | 11/20 | 0.78 |
| ▸ | PLK4 | O00444 | 2/20 | 0.57 |
| ▸ | AURKA | O14965 | 2/20 | 0.57 |
| ▸ | JAK2 | O60674 | 2/20 | 0.57 |
| ▸ | LCK | P06239 | 2/20 | 0.57 |
| ▸ | CSF1R | P07333 | 2/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.57 |
| ▸ | FLT1 | P17948 | 2/20 | 0.57 |
| ▸ | CDK2 | P24941 | 2/20 | 0.57 |
| ▸ | AXL | P30530 | 2/20 | 0.57 |
| ▸ | FLT4 | P35916 | 2/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.57 |
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | NEK2 | P51955 | 2/20 | 0.57 |
| ▸ | JAK3 | P52333 | 2/20 | 0.57 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.57 |
| ▸ | STK3 | Q13188 | 2/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14490097 | 0.92 | IKBKE (0.85) | IKBKEPLK1PLK4AURKAJAK2 | |
| SCHEMBL4038453 | 0.88 | IKBKE (1.00) | IKBKEPLK1PLK4AURKAJAK2 | |
| SCHEMBL4035225 | 0.87 | IKBKE (1.00) | IKBKEPLK1SRCTBK1 | |
| SCHEMBL5067369 | 0.86 | PLK1 (0.78) | IKBKEPLK1PLK4AURKAJAK2 | |
| SCHEMBL4041060 | 0.86 | PLK1 (0.78) | IKBKEPLK1PLK4AURKAJAK2 | |
| SCHEMBL4034641 | 0.86 | IKBKE (1.00) | IKBKEPLK1PLK4AURKAJAK2 | |
| SCHEMBL4210906 | 0.85 | IKBKE (0.74) | IKBKEPLK1PLK4AURKAJAK2 | |
| SCHEMBL4037682 | 0.80 | IKBKE (0.66) | IKBKEPLK1PLK4AURKAJAK2 | |
| SCHEMBL5410566 | 0.79 | IKBKE (0.66) | IKBKEPLK1PLK4AURKAJAK2 | |
| SCHEMBL5058163 | 0.79 | PLK1 (0.81) | IKBKEPLK1PLK4AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720864-B1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON IKK3 | GLAXO GROUP LTD (GB) | 2009-05-06 | — | — | EP | claimed |
| EP-2259787-B1 | IKKI INHIBITOR THERAPIES AND SCREENING METHODS, AND RELATED IKKI DIAGNOSTICS | UNIV MICHIGAN (US) | 2015-12-23 | — | — | EP | disclosed |