Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 7/20 | 0.66 |
| ▸ | PLK1 | P53350 | 11/20 | 0.57 |
| ▸ | NEK2 | P51955 | 4/20 | 0.48 |
| ▸ | CSF1R | P07333 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.48 |
| ▸ | STK3 | Q13188 | 3/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.48 |
| ▸ | BRSK1 | Q8TDC3 | 3/20 | 0.48 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.48 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.48 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.48 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.48 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14500931 | 0.90 | IKBKE (0.53) | IKBKEPLK1NEK2CSF1RKDR | |
| SCHEMBL4034885 | 0.89 | PLK1 (0.64) | IKBKEPLK1NEK2CSF1RKDR | |
| SCHEMBL14490097 | 0.81 | IKBKE (0.85) | IKBKEPLK1NEK2CSF1RKDR | |
| SCHEMBL4033240 | 0.80 | IKBKE (1.00) | IKBKEPLK1NEK2CSF1RKDR | |
| SCHEMBL3737267 | 0.78 | IKBKE (0.55) | IKBKEPLK1NEK2CSF1RKDR | |
| SCHEMBL5062555 | 0.78 | PLK1 (0.56) | IKBKEPLK1NEK2CSF1RKDR | |
| SCHEMBL3729503 | 0.78 | PLK1 (0.61) | IKBKEPLK1NEK2CSF1RKDR | |
| SCHEMBL5062340 | 0.77 | PLK1 (0.62) | PLK1NEK2CSF1RKDRLIMK1 | |
| SCHEMBL5062352 | 0.75 | PLK1 (0.62) | IKBKEPLK1NEK2CSF1RKDR | |
| SCHEMBL4038453 | 0.74 | IKBKE (1.00) | IKBKEPLK1NEK2CSF1RKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720864-B1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON IKK3 | GLAXO GROUP LTD (GB) | 2009-05-06 | — | — | EP | claimed |
| EP-2259787-B1 | IKKI INHIBITOR THERAPIES AND SCREENING METHODS, AND RELATED IKKI DIAGNOSTICS | UNIV MICHIGAN (US) | 2015-12-23 | — | — | EP | disclosed |
| EP-1720864-B1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON IKK3 | GLAXO GROUP LTD (GB) | 2009-05-06 | — | — | EP | disclosed |
| US-20070149519-A1 | Benzimidazol substituted thiopene derivatives with activity on ikk3 | GLAXO GROUP LIMITED (GB) | 2007-06-28 | — | — | US | disclosed |
| US-20070149519-A1 | Benzimidazol substituted thiopene derivatives with activity on ikk3 | GLAXO GROUP LIMITED (GB) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149519-A1 | Benzimidazol substituted thiopene derivatives with activity on ikk3 | IKBKE, IKBKB, TBK1 | IKBKE 1/4885PLK1 1088/4885NEK2 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.